INDOCYANINE GREEN

Safety Data Sheet
Emergency Telephone Number: CHEMTREC 1-800-424-9300       For Information call: DUDLEY 732-886-3100       
      DUDLEY CORPORATION
           	       125 Kenyon Drive
       				         	       Lakewood, New Jersey 08701
Effective Date: January 1, 2025
1. PRODUCT: Syn:  Sodium 2-[7-[3-3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolin-2-ylidene]hepta-1,3,5-trien-1-yl]-3,3-diemthyl-1-(4-sulfonatobutyl)benz  CAS No.: 3599-32-4 E-C No.:222-751-5 Weight:  774.96g/mol 	Formula: C43H47N2.NaO6S2

2. HAZARDS: GHS Class: 	Skin irritation (Category 2)	Eye irritation (Category 2A)		
			Specific target organ toxicity - single exposure (Category 3)
 Pictogram: 				                   
Signal Word:         WARNING
HAZARD STATEMENT:H319: Causes serious eye irritation.	H315: Causes skin irritation. H335: May cause respiratory irritation.	
PRECAUTIONARY STATEMENT: P261: Avoid breathing dust/spray/ fume/gas/ mist/ vapors. P264: wash skin thoroughly after handling.	P271: Use only outdoors or in well-ventilated area. P405: Store locked up.	P280: Wear protective gloves/eye & face protection. P302 + P352: If on skin: Wash with plenty of soap & water. P304 + P340: If inhaled: remove to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: If in Eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present & easy to do so. Continue rinsing. P312: Call Poison Center or doctor/physician if you feel unwell. P321: Specific treatment (see supplemental first aid instructions). P332 + P313: If skin irritation occurs: consult physician.  P337+P313: If eye irritation occurs: consult physician. P362: Take off contaminated clothing and wash before reuse. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P501: Dispose of contents/container to an approved waste disposal plant.

HMIS Class: Health hazard  2, Flammability   0,  Physical hazards   0			
NFPA Rating: Health hazard  2, Fire     0, Reactivity hazard   0
2.3: Other Hazards: none

3. COMPOSITION / INFO ON INGREDIENTS: 
Chemical 							    CAS No.	    Percent		
Sodium 2-[7-[3-3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolin-2-ylidene]hepta-1,3,5-trien-1-yl]
-3,3-diemthyl-1-(4-sulfonatobutyl)benz	            			    3599-32-4                 100%                  

4. FIRST AID: Eyes: Rinse immediately with plenty of water.  Skin: Rinse with plenty of soap & water. 
Ingestion: Do not induce vomiting without medical advice. Rinse with water. 
Inhalation: Move to fresh air.  Physician: Treat symptomatically and supportively. 

5. FIRE FIGHTING: Info: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH & full PPE. Irritating & highly toxic gases may be generated by thermal decomp/combustion. Hazards: Carbon, nitrogen, sulfur & Sodium oxides. Extinguishing: Use water spray, dry chemical, carbon dioxide, or alcohol-resistant foam.

6. ACCIDENTAL RELEASE: Info: Use proper PPE as indicated in Section 8. Spills: Clean up spills immediately, observing precaution in the PPE section. Avoid generating dusty conditions.

7. HANDLING & STORAGE: Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. 

8. EXPOSURE: Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits.

Chemical 				ACGIH		NIOSH		OSHA-Final / Vacated PELs
1H-Benzeindolium, 2-7-1,3dihydro-1,		None listed	None listed	None Listed
dymethyl-3-(4-sulfobuty)

PPE: Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA’s eye and face protection regulations in 29 CFR 1910-133 or European EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. 0.11mm thick nitrile. Clothing: Wear appropriate protective clothing to minimize contact with skin. 
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910-134 or European Standard EN 149 approved respirators when necessary.

9. PHYSICAL & CHEM: Appearance: Brown powder

10. STABILITY & REACTIVITY: Stability: Stable under normal temp/pressures. Avoid: Incompatibles, strong oxidants, exposure to moist air or water. Incompatibilities: Strong oxidizing materials. Haz Decomp: see section 5

11. TOXIC INFO: RCTES#: DE 3150000 LD50: TDLo-intravenous mouse 23.28, 23.3,  & 60mg/kg – rat 87mg/kg, 
Carcinogenicity: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.

12. ECOLOGICAL INFO: Fate/ Toxicity: No info.

13. DISPOSAL CONSIDERATIONS: Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: None listed.

14. TRANSPORT INFO: Not regulated.

15. REGULATORY INFO: SARA 311/312: Acute Health Hazard
Section 302 (TPQ/RQ) None of the chemicals in this material have a TPQ/RQ.
Section 313 No chemicals are reportable under Section 313.
State CAS# 3599-32-4 is not present on state lists from CA, MN, MA, FL. 
PA & NJ Right to Know: CARDIOGREEN  CAS#3599-32-4
California Prop.65: None of the chemicals are known to cause cancer, birth defects, or any other reproductive harm.

EUROPEAN/INTERNATIONAL REGULATIONS: European Labeling in Accordance with EC Directives
Hazard Symbols: XI  WGK (Water Danger/Protection) CAS# 3599-32-4: No information available.
Canada: CAS# 3599-32-4:is listed on Canada’s NDSL list.	WHIMS: Not available.
CAS# 3599-32-4 is not listed on Canada’s Ingredient Disclosure List.

16. DISCLAIMER INFO: DUDLEY CORPORATION provides the information herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this.  Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. DUDLEY CORPORATION makes no representations or warranties, either expressed or implied, including without limitation and warranties of merchantability, fitness for a particular purpose with respect to the information set forth herein or to the product to which the information refers. Accordingly, DUDLEY CORPORATION will not be responsible for damages resulting from the use of or reliance upon this information.