1,4-DITHIOTHREITOL (DTT)

Safety Data Sheet
Emergency Telephone Number: CHEMTREC 1-800-424-9300       For Information call: DUDLEY 732-886-3100       
      DUDLEY CORPORATION
           	       125 Kenyon Drive
       				         	       Lakewood, New Jersey 08701
Effective Date: January 1, 2025	
1. PRODUCT: Syns:  DTT, Cleland’s reagent, threo-1,4-Dimercapto-2,3-butanediol 
CAS No.: 3483-12-3       E-C No.:222-468-7	Weight:  154.25g/mol 	Formula: C4H10O2S2

2. HAZARDS: GHS: Acute toxicity, Oral (Category 4) Acute Aquatic Hazard (Category 3) Skin Irritation (Cat 2)	
Serious Eye Damage (Cat.1)
 Pictogram: 					
Signal Word:         DANGER
HAZARD STATEMENT(S): H302: Harmful if swallowed. H402: Harmful to aquatic life. H315: Causes skin irritation H318: Causes serious eye damage
PRECAUTIONARY STATEMENT(S): P264: Wash skin thoroughly after handling. P270: Do not drink, eat, smoke, when using this product. P273: Avoid release to the environment.  P280: Wear Protective gloves, eye, face protection. P305 + P351 + P338 + P310: Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a Poison Center / Doctor. P302 +P352: If on Skin: wash with plenty of soap and water. P332 + P313: If skin irritation occurs: Get medical advice. 
P301 + P312 +P330: If swallowed: Call Poison Center or doctor/physician if you feel unwell, Rinse mouth.
P501: Dispose of contents/container to an approved waste disposal plant. P362: Take off contaminated clothing and wash before reuse. 

HMIS Classification: Health hazard  2, Flammability  1,  Physical hazards   0			
NFPA Rating: Health hazard  2, Fire     1, Reactivity hazard   0
2.3: Other Hazards: none

3. COMPOSITION / INFO ON INGREDIENTS: 
Chemical Name					 CAS No.	 	Percent		
(R*,R*)-1,4-Dimercaptobutane-2,3-diol	                  	 3483-12-3               99%                  

4. FIRST AID: Eyes: Rinse with plenty of water for 15 min. Skin:. Rinse with plenty of soap & water. 
Ingestion: Do not induce vomiting without medical advice. Rinse with water. Inhalation: Move to fresh air.  
Physician: Treat symptomatically and supportively. 

5. FIREFIGHTING: Info: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH & full PPE. Dust at sufficient concentrations can form explosive mixtures with air. Combustion generates toxic fumes. Irritating and highly toxic gases may be generated by thermal decom/ combustion. Hazards: Carbon & Sulfur oxides Extinguishing: Use water spray, dry chemical, alcohol-resistant foam or carbon dioxide.   Flash Pt: 113˚C(235˚F) 

6. ACCIDENTAL RELEASE: Info: Use proper PPE as indicated in Section 8. Spills: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

7. HANDLING & STORAGE: Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a cool, dry, well-ventilated area away from incompatible substances. 2-8°C.

8. EXPOSURE CONTROLS, PPE: Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. 
Chemical Name			ACGIH			NIOSH		OSHA Final/ Vacated PELs
Dithiothreitol			None listed		None listed		None listed

PPE: Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA’s eye and face protection regulations in 29 CFR 1910.133 or European Standard EN 166. Skin: Wear appropriate protective gloves to prevent skin exposure. 0.11 mm thick nitrile. Clothing: Wear appropriate protective clothing to minimize contact with skin. 
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Always use 
a NIOSH or European Standard EN 149 approved respirator when necessary.

9. PHYSICAL & CHEM: White crystalline powder solid Odor: Characteristic odor (sulfur). pH: 4-6 at 15.4g/l at 25˚C Solubility: 15.4 g/l at 20˚C (68˚F) Melting Pt: 41-44˚C (106-111˚F) Partition coefficient: n-octanol/water: log Pow: 0.05	Boiling Pt.: 270-272°C Vapor Pressure: <0.1 hPa at 25°C Density: 1.377 g/cm3 at 20°C Bulk density ca. 300 kg/m3

10. STABILITY & REACTIVITY: Stability: Stable under normal temp / pressures. Avoid: Incompatibles, dust generation. Incompatibilities: Oxidizing Agents, bases, reducing agents, alkali metals. Hazardous Decomp: see section 5

11. TOXICOLOGICAL INFO: RTECS# EK1610000	LD50/LC50: LD50-Oral-rat- 300-2,000 mg/kg Skin irritation – 1h
Carcinogenicity: CAS# 3483-12-3: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other Studies: Liver irregularities   Biodegradability – aerobic Exposure time 43 d result 50% not readily biodegradable

12. ECOLOGICAL INFO: Environmental Fate/Toxicity:  LC50-Water flea – 34.8 mg/l-48h NOEC – 25mg/l – 48h

13. DISPOSAL CONSIDERATIONS: Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: None listed.

14.TRANSPORT INFO: DOT & IMDG: Not regulated.    
IATA: UN 3335, Aviation regulated solid, n.o.s. ((R*,R*)-1,4-Dimercapto-2,3-butanediol), 9, III  

15. REGULATORY INFO: SARA 311/312:  Acute Health Hazard, Chronic Health Hazard
Section 302 (RQ) and Section 302 (TPQ) None of the chemicals in this material have an RQ or TPQ.
Section 313 No chemicals are reportable under Section 313.
State CAS# 3483-12-3 is not present on state lists from CA, MN, MA, FL. 
PA & NJ Right to Know: No information available.
California Prop.65: None of the chemicals are known to cause cancer, birth defects, or any other reproductive harm.

EUROPEAN / INTERNATIONAL REGULATIONS European Labeling in Accordance with EC Directives
Hazard Symbols Not available   WGK (Water Danger/Protection) CAS#3483-12-3: No information available.
Canada DSL/NDSLCAS# 3483-12-3 is listed on Canada’s DSL list.  Canada WHMIS: Not available

16. DISCLAIMER INFO: DUDLEY CORPORATION provides the information herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this.  Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. DUDLEY CORPORATION makes no representations or warranties, either expressed or implied, including without limitation and warranties of merchantability, fitness for a particular purpose with respect to the information set forth herein or to the product to which the information refers. Accordingly, DUDLEY CORPORATION will not be responsible for damages resulting from the use of or reliance upon this information.